Transforming growth factor beta contributes to progressive diabetic nephropathy
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چکیده
منابع مشابه
Transforming growth factor beta contributes to progressive diabetic nephropathy.
R failure is a common and serious complication of longstanding diabetes mellitus. Diabetes is now the most common cause of end-stage renal failure requiring dialysis in the United States, accounting for almost 40% of all new dialysis patients (1). Moreover, the incidence of renal failure caused by diabetes, particularly type II diabetes, is rising dramatically worldwide (2). Compounding the tra...
متن کاملTransforming growth factor-β1 and diabetic nephropathy.
Transforming growth factor-β1 (TGF-β1) is established to be involved in the pathogenesis of diabetic nephropathy. The diabetic milieu enhances oxidative stress and induces the expression of TGF-β1. TGF-β1 promotes cell hypertrophy and extracellular matrix accumulation in the mesangium, which decreases glomerular filtration rate and leads to chronic renal failure. Recently, TGF-β1 has been demon...
متن کاملDo changes in transglutaminase activity alter latent transforming growth factor beta activation in experimental diabetic nephropathy?
BACKGROUND Diabetic nephropathy is the leading cause of end-stage kidney failure worldwide. It is characterized by excessive extracellular matrix accumulation. Transforming growth factor beta 1 (TGF-β1) is a fibrogenic cytokine playing a major role in the healing process and scarring by regulating extracellular matrix turnover, cell proliferation and epithelial mesanchymal transdifferentiation....
متن کاملTransforming growth factor-beta in human diabetic nephropathy: effects of ACE inhibition.
OBJECTIVE Studies in rodent models have suggested that reduction in renal transforming growth factor (TGF)-beta1 may underlie the renoprotective effects of the renin-angiotensin system (RAS) blockade. However, the role of the RAS blockade in abrogating TGF-beta in human disease is unknown. Accordingly, we sought to examine TGF-beta gene expression and biological activity in human renal biopsies...
متن کاملChanges of transforming growth factor beta 1 in patients with type 2 diabetes and diabetic nephropathy
BACKGROUND The existing evidence indicates increased levels of transforming growth factor beta 1 (TGF-β1) in patients with type 2 diabetes mellitus (T2DM) and those with type 2 diabetic nephropathy (T2DN); yet no meta-analysis displays a reliable result. Here we conducted a meta-analysis to evaluate characteristic changes of TGF-β1 in T2DM and diabetic nephropathy. METHODS A systematic search...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.97.14.7667